Results
| PMID | 24992181 |
| Gene Name | RERG |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | ESR2 |
| Other associated phenotypes |
Endometriosis |
|
Mol Endocrinol. 2014 Aug;28(8):1304-15. doi: 10.1210/me.2013-1421. Epub 2014 Jul Monsivais, D| Dyson, M T| Yin, P| Coon, J S| Navarro, A| Feng, G| Malpani, S S| Ono, M| Ercan, C M| Wei, J J| Pavone, M E| Su, E| Bulun, S E Division of Reproductive Biology Research (D.M., M.T.D., P.Y., J.S.C., A.N., S.S.M., M.O., C.M.E., M.E.P., E.S., S.E.B.), Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Northwestern University Biomedical In endometriosis, stromal and epithelial cells from the endometrium form extrauterine lesions and persist in response to estrogen (E2) and prostaglandin E2 (PGE2). Stromal cells produce excessive quantities of estrogen and PGE2 in a feed-forward manner. However, it is unknown how estrogen stimulates cell proliferation and survival for the establishment and persistence of disease. Previous studies suggest that estrogen receptor-beta (ERbeta) is strikingly overexpressed in endometriotic stromal cells. Thus, we integrated genome-wide ERbeta binding data from previously published studies in breast cells and gene expression profiles in human endometriosis and endometrial tissues (total sample number = 81) and identified Ras-like, estrogen-regulated, growth inhibitor (RERG) as an ERbeta target. Estradiol potently induced RERG mRNA and protein levels in primary endometriotic stromal cells. Chromatin immunoprecipitation demonstrated E2-induced enrichment of ERbeta at the RERG promoter region. PGE2 via protein kinase A phosphorylated RERG and enhanced the nuclear translocation of RERG. RERG induced the proliferation of primary endometriotic cells. Overall, we demonstrated that E2/ERbeta and PGE2 integrate at RERG, leading to increased endometriotic cell proliferation and represents a novel candidate for therapeutic intervention. Mesh Terms: Adult| Cell Nucleus/metabolism| *Cell Proliferation| Dinoprostone/*physiology| Endometriosis/*metabolism/pathology| Estradiol/physiology| Estrogen Receptor beta/*physiology| Female| GTP Phosphohydrolases/*metabolism| Gene Expression Regulation| |
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